Pages

Showing posts with label tyrosine hydroxylase. Show all posts
Showing posts with label tyrosine hydroxylase. Show all posts

Wednesday, June 20, 2012

"Bath Salts" and methamphetamine have a different toxicological profile?

There have been a number of news reports recently about people who display abnormal aggression while using "bath salts".  The putative active ingredient in these preparations is mephedrone, a combination of methamphetamine and cathinone.  While methamphetamine is neurotoxic to the terminal button of striatal neurons, a report in The Journal of Neurochemistry suggests that mephedrone lacks methamphetamine's impact in this model.   Despite the similarities between mephedrone and methamphetamine, mephedrone does not produce methamphetamine's change in dopamine, dopamine transporter, or tyrosine hydroxylase.

Reference - Angoa-Perez et al. (2012). Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum  J Neurosci 120(6): 1097