Thursday, February 23, 2012

Modafinil for the treatment of methamphetamine abuse?

In a recent  article in the journal Drug and Alcohol Dependence Ann L. Anderson and colleagues evaluated the efficacy of the psychostimulant modafinil as a treatment for methamphetamine abuse. This was a relatively-large study of patients dependent on methamphetamine who received (double-blind design) modafinil (200 or 400 mg) or placebo over twelve weeks.  Despite the animal research that suggests that modafinil could block or replace methamphetamine's "addictive" effects, there was no significant impact of modafinil treatment on methamphetamine use in these patients.  The authors suggest a problem was that the patients did not comply with the modafinil treatment regimen.

Reference - Modafinil for the Treatment of Methamphetamine Dependence, A.L. Anderson, et. al. (2012) Drug & Alcohol Dependence 120: 135.


  1. I'm a little confused, because Modafinil is used to treat narcolepsy or day time sleepiness. I don't see how it could be used for the treatment of methamphetamine abuse.

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